Alzheimer's Disease Model

Alzheimer's Disease Model

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the world which causes dementia and affects about 36 million people worldwide. The pathogenesis is still unclear, although may support the Amyloid cascade theory, which is based on abnormal APP processing and clearance, leading to the formation of toxic amyloid oligomers, fibrils and extracellular amyloid plaques. Amyloid seems to trigger the tau protein dependent neurofibrillary pathology, which is another pathological hallmark of AD. The whole process is long-lasting and may start decades before the first disease symptoms occur. In spite of enormous research efforts, so far no efficient treatment is available. For successful drug development, validated predictive animal models are needed. Animal models mimicking human Alzheimer's Disease allow us to test therapeutic potentials and investigate disease progression, contributing to improvement of quality of life for humans. Alzheimer's Disease Model https://acroscell.creative-bioarray.com/alzheimer-s-disease-model.html